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KMID : 0363320050260020431
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 2 p.431 ~ p.439
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Effects of Flos Bombacis Malabarici(FBM) on the Monosodium Urate(MSU)-induced Gout Model in Rats
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Chae Eun-Young
Cho Chung-Sik
Kim Cheol-Jung
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Abstract
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Objective: The aim was to identify the inhibitory effects of Flos Bombacis Malabarici(FBM) on Monosodium Urate (MSU)-induced gout in rats.
Materials and Methods: After pretreatment of FBM I (50mg/kg), FBM II (125mg/kg) for seven days followed by injection of MSU solution, the various indicators related to gout were measured, such as hematological and serum levels and including joint inflammation. Also, it was investigated whether FBM directly inhibits the activity of xanthine oxidase in vitro.
Results: As a result of this study, FBM didn’t show the cytotoxicity in Jurkat cells, but it showed significant inhibition of activity of xanthine oxidase in vitro. FBM slightly inhibited joint inflammation induced by MSU though not with statistical significance. FBM partially decreased MSU-induced AST, ALT, BUN, creatinine, WBC, ESR elevation and significantly decreased MSU-induced uric acid in serum.
Conclusion: These results suggest that FBM has therapeutic effects that are applicable to prevention and treatment of gout. and should be further investigated.
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KEYWORD
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Gout, Flos Bombacis Malabarici(FBM), Monosodium Urate(MSU), xanthine oxidase(XO)
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